Sherlock Holmes is consulted in his Baker Street apartment by Dr. Mortimer, a physician now living on the fringes of Dartmoor. He gives Holmes and Watson an account of a centuries-old legend, in which a hell-hound slaughtered the debauched heir of the Baskerville family who had been in lecherous pursuit of an innocent maiden across the moor. The same hound is reputed to have harrowed several of the subsequent heirs to the estate. This ancient story might be dismissed as mere fancy, but for the fact that the elderly Sir Charles Baskerville recently died in very mysterious circumstances, apparently fleeing in terror from something which came from the moor. Dr. Mortimer is concerned that the new heir, Sir Henry, just returned from Canada, may be at risk from this supernatural beast. Holmes is intrigued, but being too busy to go himself, sends Dr. Watson to accompany Sir Henry to the ancestral home on Dartmoor and to report anything suspicious.